In Memoriam: Samay Jain.
Pallanck, L., Greenamyre, J.T. Neurodegenerative disease: pink, parkin and the brain. Nature. 441(7097): 1058, 2006.
Berman, S.B., Greenamyre, J.T. Update on Huntington's disease. Curr Neurol Neurosci Rep. 6(4): 281-6, 2006.
Richardson, J.R., Caudle, W.M., Guillot, T.S., Watson, J.L., Nakamaru-Ogiso, E., Seo, B.B., Sherer, T.B., Greenamyre, J.T., Yagi, T., Matsuno-Yagi, A. and Miller, G.W. Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicol Sci. 95(1): 196-204,2007. Epub 2006 Oct 12.
Sherer, T.B., Richardson, J.R., Testa, C.M., Seo, B.B., Panov, A.V., Yagi, T., Matsuno-Yagi, A., Miller, G.W. and Greenamyre, J.T. Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease. J Neurochem. 100(6):1469-79, 2007. Epub 2007 Jan 4.
Greenamyre, J.T. Huntington's disease--making connections. N Engl J Med. 356(5): 518-20, 2007.
Rocha EM, De Miranda BR, Castro S, Drolet R, Keeney M, Di Maio R, Kofler J, Hastings TG, Greenamyre JT, LRRK2 inhibition prevents endolysosomal deficits seen in human ParkinsonӮs disease, Neurobiol Dis, in press, 2019.
De Miranda BR, Rocha EM, Bai Q, El Ayadi A, Hinkle D, Burton EA and Greenamyre, JT, Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease, Neurobiol Dis, doi: 10.1016/j.nbd.2018.04.008.
Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan A, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT, LRRK2 activation in idiopathic Parkinson disease, Sci Transl Med., 10, eaar5429 (2018) doi: 10.1126/scitranslmed.aar5429.
Howlett EH, Jensen N, Belmonte F, Zafar F, Hu X, Kluss J, Schعle B, Kaufman BA, Greenamyre JT and Sanders LH, LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase-dependent and inhibition restores mtDNA integrity in Parkinson”Æs disease, Human Mol Genet 26:4340-4351, 2017.
Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, Hu X, McCoy J, Chu CT, Burton EA, Hastings TG, Greenamyre JT. ¦Į-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease. Sci Transl Med 2016;8:342ra78.
Zharikov A, Cannon JR, Tapias V, Bai Q, Horowitz M, Shah V, El Ayadi A, Hastings TG, Greenamyre JT, Burton EA, shRNA targeting ¦Į-synuclein prevents neurodegeneration in a Parkinson”Æs disease model, J Clin Invest 125:2721-35, 2015.
Sanders LH, Laganiere J, Cooper O, Mak S, Vu BJ, Huang YA; Paschon D, Vangipuram M; Sundararajan R, Urnov F, Langston JW, Gregory P, Zhang HS, Greenamyre JT*, Isacson O, Schule B, LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction, Neurobiol Dis 62:381-6, 2014.
Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino P-G, McLendon C, Kim J-H, Lund S, Na H-M, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, Cookson MR, Greenamyre JT, Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1 and ¦Į-synuclein and the ubiquitin-proteasome system, Neurobiol Dis. 22:404-420, 2006.
AV Panov, C-A Gutekunst, BR Leavitt, MR Hayden, JR Burke, WJ Strittmatter, JT Greenamyre, Early mitochondrial calcium defects in HuntingtonӮs disease are a direct effect of polyglutamines, Nature Neuroscience 5:731-736, 2002.
Betarbet, R, Sherer, TB, MacKenzie, G, Garcia-Osuna, M, Panov, AV and Greenamyre, JT, Chronic systemic pesticide exposure reproduces features of ParkinsonӮs disease, Nature Neuroscience 3:1301-1306, 2000.